反应详情

温度

30 °C

30 g (170 mmol) of 2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline are dissolved in 400 ml of acetonitrile, and 94 g (0.68 mol) of potassium carbonate are added. 84 g (174 mmol) of tetrabutylammonium tribromide are subsequently added a little at a time with vigorous stirring at temperatures<30° C. For work-up, the solid is filtered off with suction and the filtrate is diluted with methylene chloride and extracted with water. The solvent is stripped off and the residue is again taken up in methyl tert-butyl ether and washed twice with water. The organic phase is dried and concentrated.

1. filtrationFor work-up, the solid is filtered off with suction
2. additionthe filtrate is diluted with methylene chloride
3. extractionextracted with water
4. washwashed twice with water
5. customThe organic phase is dried
6. concentrationconcentrated