2-Thiopheneacetic acid → HCID 20493324, compound

HRID 434341Notes

Reaction equation

HRID 434341 reaction equation
C([O:3][C:4]([CH2:6][N:7]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9](=[CH2:15])[C:8]1=[O:16])=[O:5])C.[C:17]([CH2:20]N1CCCCCC(=C)C1=O)(O)=[O:18].[S:31]1C=CC=C1CC(O)=O>>[C:4]([CH2:6][N:7]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH:9]([CH2:15][S:31][C:17](=[O:18])[CH3:20])[C:8]1=[O:16])([OH:3])=[O:5]

Participants

4

Reactant 3

HCID 159702-Thiopheneacetic acidHCID 20493318HCID 20493318, compoundHCID 20493327HCID 20493327, compound

Product 1

HCID 20493324HCID 20493324, compound

Procedure

Hydrolyze 100 mg 1-ethoxycarbonylmethyl-3-methyleneperhydroazocin-2-one (prepared as in Example 1) with base as described in Example 3. Treat the resulting 1-carboxymethyl-3-methyleneperhydroazocin-2-one with thiolacetic acid as described in Example 3 and isolate the desired 1-carboxymethyl-3-acetylthiomethylperhydroazocin-2-one.

Sources & evidence

ORD record
ord-f453631ae53645fda111bca21d8e22d0
Source dataset
uspto-grants-1983_08
Patent number
US04396616

Reaction notes

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