反应详情

A mixture of 1-(4-carbomethoxyphenyl)propan-2-one (17.3 g), ethan-1,2-diol (5.6 g) and p-toluenesulphonic acid (200 ml) in benzene (150 ml) was refluxed under a Dean and Stark head until the theoretical amount of water had been collected (ca. 4 hours). The solvent was evaporated and the residue was partitioned between sodium bicarbonate solution and ether. The ethereal extract was washed with water, dried, evaporated and distilled to give 15.7 g (74%), bp 136-140/1.5 mm.

1. customhad been collected (ca. 4 hours)
2. customThe solvent was evaporated
3. customthe residue was partitioned between sodium bicarbonate solution and ether
4. extractionThe ethereal extract
5. washwas washed with water
6. customdried
7. customevaporated
8. distillationdistilled
9. customto give 15.7 g (74%), bp 136-140/1.5 mm