Methylamine → HCID 178485120, compound

HRID 434401Notes

Reaction equation

HRID 434401 reaction equation
[C:1]([N:3]([CH:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])[C:4](=[NH:7])SC)#[N:2].[CH3:22][NH2:23]>C(O)C>[C:1]([N:3]([CH:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])[C:4]([NH:23][CH3:22])=[NH:7])#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86737986HCID 86737986, compound

Product 1

HCID 178485120HCID 178485120, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A mixture consisting of 5.9 g (0.02 mol) of N-cyano-S-methyl-N-[α-(2-pyridyl)orthomethylbenzyl]isothiourea prepared in (a), 30 ml of 20% solution of methylamine in ethanol and 70 ml of ethanol was prepared and reacted at room temperature overnight. The reaction solution was concentrated under a reduced pressure. The residue was recrystallized from ethyl acetate to produce 4.7 g of the subject material, N-cyano-N'-methyl-N-[α-(2-pyridyl)orthomethylbenzyl]guanidine (yield: 85.0%).

Workup

  1. customwas prepared
  2. customreacted at room temperature overnight
  3. concentrationThe reaction solution was concentrated under a reduced pressure
  4. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-4a1d1945f03843d5a29680c6325da048
Source dataset
uspto-grants-1983_08
Patent number
US04396764

Reaction notes

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