HCID 86738963, compound → HCID 13187471, compound

HRID 434411Notes

Reaction equation

HRID 434411 reaction equation
[CH3:1][C:2]([CH3:32])([CH3:31])[C:3](=[O:30])[O:4][CH2:5][O:6][P:7]([CH2:19][C:20]([O:22]CC1C=CC=CC=1)=[O:21])([CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:8]>C(OCC)(=O)C.[Pd]>[CH3:1][C:2]([CH3:32])([CH3:31])[C:3](=[O:30])[O:4][CH2:5][O:6][P:7]([CH2:19][C:20]([OH:22])=[O:21])([CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:8]

Participants

4

Reactant 1

HCID 86738963HCID 86738963, compound

Product 1

HCID 13187471HCID 13187471, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

[[(2,2-Dimethyl-1-oxopropoxy)methoxy](4-phenylbutyl)phosphinyl]acetic acid, phenylmethyl ester (2.95 g, 6.4 mmol) in 75 ml of ethyl acetate was hydrogenated at 48 psi over 10% palladium on charcoal catalyst (0.4 g) for 1 hour. The mixture was filtered through Celite and evaporated to dryness to give the title acid as a colorless oil which solidified to a solid, melting point 48°-50° C.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-f5e726f6842743c584a741412d4936f5
Source dataset
uspto-grants-1983_08
Patent number
US04396772

Reaction notes

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