反应详情

To a chilled and stirred mixture of 2,3-dihydroindole-2-carboxylic acid ethyl ester (14.34 g.), triethylamine (7.65 g.) and anhydrous ether (600 ml.) was added dropwise acryloyl chloride (7.1 g.) dissolved in a small amount of ether. The ice bath was removed, and the reaction mixture was stirred at room temperature for 4 hours. The reaction mixture was chilled in ice, then a precipitate was removed by filtration. The filter residue was washed with ether. The combined filtrate and washing were washed with water, then with saline, and dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure on a rotary evaporator gave the titled compound (14.4 g.) as an oil.

1. temperatureTo a chilled
2. customThe ice bath was removed
3. stirringthe reaction mixture was stirred at room temperature for 4 hours
4. temperatureThe reaction mixture was chilled in ice
5. customa precipitate was removed by filtration
6. washThe filter residue was washed with ether
7. washThe combined filtrate and washing
8. washwere washed with water
9. dry with materialwith saline, and dried over anhydrous magnesium sulfate
10. customEvaporation of the solvent under reduced pressure
11. customon a rotary evaporator