2-Amino-3-pentanone hydrochloride → HCID 178470245, compound

HRID 43445Notes

Reaction equation

HRID 43445 reaction equation
Cl.[NH2:2][CH:3]([C:5](=O)[CH2:6][CH3:7])[CH3:4].F[B-](F)(F)F.[NH:14]=[C:15](SC)[C:16]([O:18][CH2:19][CH3:20])=[O:17]>>[CH2:6]([C:5]1[NH:14][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:2][C:3]=1[CH3:4])[CH3:7]

Participants

3

Reactant 2

HCID 193696302-Amino-3-pentanone hydrochlorideHCID 86648451Ethyl imino(methylthio)acetate tetrafluoroborate

Product 1

HCID 178470245HCID 178470245, compoundYield 60%

Procedure

The same operation as in Example (lb) was performed using 2-amino-pentan-3-one hydrochloride obtained in Example (15c) (about 10 mmol) and ethyl imino(methylthio)acetate tetrafluoroborate obtained according to a method known in the literature (J. Med. Chem., 38, 1995, 2196-2201) (about 10 mmol), to obtain 1.1 g of the title compound as a yellow solid (60%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-32f6d9d3694047ab9ccad3ae945efda4
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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