HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dabco → 2-[(dimethylamino)sulfonylmethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | 2-Amino-4,6-dimethoxypyrimidine | HCID 118946 | — |
| Reactant | 2-[(Dimethylsulfamoyl)methyl]benzene-1-sulfonyl isocyanate | HCID 13178729 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-[(dimethylamino)sulfonylmethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide | HCID 20492584 | 78.8% |
Reaction Steps
A mixture of 2.6 g of the product of Example 5, 0.9 g of 2-amino-4,6-dimethoxypyrimidine and a few crystals of DABCO in 15 ml of dry acetonitrile was heated at 50°-55° for 1 hour under a nitrogen atmosphere, then stirred overnight at room temperature. The precipitate was filtered off, washed with acetonitrile and dried to give 2.1 g of 2-[(dimethylamino)sulfonylmethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide, m.p. 172°-176°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04397679 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-8dec5d50d7f140b5a4959d613fded792 |
| Source note | uspto-grants-1983_08 |