HRID434462

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9237

1,4-Diazabicyclo[2.2.2]octane

C6H12N2

HCID118946

4,6-Dimethoxy-2-pyrimidinamine

C6H9N3O2

结构：CN(C)S(=O)(=O)Cc1ccccc1S(=O)(=O)N=C=O

HCID13178729

2-[(Dimethylsulfamoyl)methyl]benzene-1-sulfonyl isocyanate

C10H12N2O5S2

PRODUCTS

生成物

结构：COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2CS(=O)(=O)N(C)C)n1

HCID20492584

未命名化合物

收率 78.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A mixture of 2.6 g of the product of Example 5, 0.9 g of 2-amino-4,6-dimethoxypyrimidine and a few crystals of DABCO in 15 ml of dry acetonitrile was heated at 50°-55° for 1 hour under a nitrogen atmosphere, then stirred overnight at room temperature. The precipitate was filtered off, washed with acetonitrile and dried to give 2.1 g of 2-[(dimethylamino)sulfonylmethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide, m.p. 172°-176°.

WORKUP

后处理

filtrationThe precipitate was filtered off
washwashed with acetonitrile
customdried