反应详情

4-Chloro-3,5-dinitrobenzotrifluoride (5.4 grams; 0.02 mole) dissolved in toluene (50 ml) and a solution of N-ethyl-N-(2,2-diethoxyethyl)amine (3.2 grams; 0.02 mole) and triethylamine (2.02 grams; 0.02 mole in toluene (50 ml) were charged into a glass reaction vessel equipped with stirrer, thermometer and reflux condenser. The mixture was heated at reflux overnight resulting in the formation of a precipitate. The reaction mixture was then filtered and the filtrate was washed with water, dried and stripped of solvent to yield the desired product N-ethyl-N-(2,2-diethoxyethyl)-2,6-dinitro-4-trifluoromethylaniline.

1. customequipped with stirrer
2. temperaturethermometer and reflux condenser
3. temperatureThe mixture was heated
4. temperatureat reflux overnight
5. customresulting in the formation of a precipitate
6. filtrationThe reaction mixture was then filtered
7. washthe filtrate was washed with water
8. customdried