Ethylamine → HCID 13175522, compound

HRID 434475Notes

Reaction equation

HRID 434475 reaction equation
[CH2:1]([NH2:3])[CH3:2].[CH3:4][C:5]1([CH2:10]Br)[O:9][CH2:8][CH2:7][O:6]1.[OH-].[Na+]>CCOCC>[CH2:1]([NH:3][CH2:4][C:5]1([CH3:10])[O:9][CH2:8][CH2:7][O:6]1)[CH3:2]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 14798Sodium HydroxideHCID 2646042-(Bromomethyl)-2-methyl-1,3-dioxolane

Product 1

HCID 13175522HCID 13175522, compoundYield 40.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
120 °C

Procedure

Ethylamine (115 grams; 1.77 mole) and 2-methyl-2-bromomethyl-1,3-dioxolane (32 grams; 0.177 mole) were placed in a stainless steel bomb and placed on a steam bath for 5 hours. The temperature of the mixture was raised to 120° C. for 15 hours. The mixture was cooled and ether (200 ml) added to it. Sodium hydroxide (25 grams) was added and the ether layer separated and dried over magnesium sulfate. The ether was evaporated leaving the desired product (10.3 grams) as identified by nuclear magnetic resonance.

Workup

  1. temperatureThe mixture was cooled
  2. customthe ether layer separated
  3. dry with materialdried over magnesium sulfate
  4. customThe ether was evaporated

Sources & evidence

ORD record
ord-99dc61d03dbb414486c50c48d10b71db
Source dataset
uspto-grants-1983_08
Patent number
US04397677

Reaction notes

Loading…