2,3-Dibromopropanenitrile → 2-Cyano-1-(3-fluorobenzyloxy)-aziridine
Reaction equation
Br[CH:2]([CH2:5]Br)[C:3]#[N:4].[F:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[CH2:11][O:12][NH2:13]>>[C:3]([CH:2]1[CH2:5][N:13]1[O:12][CH2:11][C:10]1[CH:14]=[CH:15][CH:16]=[C:8]([F:7])[CH:9]=1)#[N:4]Participants
3
Procedure
Analogously to Example 4, by the reaction of 2,3-dibromopropionitrile with O-(3-fluorobenzyl)-hydroxylamine, there is obtained 2-cyano-1-(3-fluorobenzyloxy)-aziridine (see Example 4d). The two invertomers can be separated by column chromatographic separation on silica gel (elution agent diethyl ether/ligroin 1/1 v/v) to give:
Sources & evidence
- ORD record
- ord-c368cbeeb82b41f0bcc45d66169943a6
- Source dataset
- uspto-grants-1983_08
- Patent number
- US04397848
Reaction notes
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