HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dibromopropanenitrile → 2-Cyano-1-(3-fluorobenzyloxy)-aziridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dibromopropanenitrile | HCID 107299 | — |
| Reactant | O-[(3-fluorophenyl)methyl]hydroxylamine | HCID 2737767 | — |
| Product | 2-Cyano-1-(3-fluorobenzyloxy)-aziridine | HCID 20284029 | — |
Reaction Steps
Analogously to Example 4, by the reaction of 2,3-dibromopropionitrile with O-(3-fluorobenzyl)-hydroxylamine, there is obtained 2-cyano-1-(3-fluorobenzyloxy)-aziridine (see Example 4d). The two invertomers can be separated by column chromatographic separation on silica gel (elution agent diethyl ether/ligroin 1/1 v/v) to give:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04397848 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-c368cbeeb82b41f0bcc45d66169943a6 |
| Source note | uspto-grants-1983_08 |