Triethylamine → HCID 86738965, compound

Participants

Reaction Steps

A solution of cinnamoyl chloride (3.32 g) in methylene chloride (25 ml) is added dropwise to a solution of methyl, α,α-dimethyl-1-piperazinepentanoate (4.56 g) in methylene chloride (25 ml) containing triethylamine (2.0 g) and the mixture is stirred overnight at room temperature. The solution is washed with water, dried, and distilled to yield the product methyl α,α-dimethyl-4-(1-oxo-3-phenyl-2-propenyl)-1-piperazine pentanoate, mp 76° following crystallization from isopropyl ether.

Provenance & Evidence