Triethylamine → HCID 86738965, compound

HRID 434503Notes

Reaction equation

HRID 434503 reaction equation
[C:1](Cl)(=[O:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:12][C:13]([CH3:26])([CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)[C:14]([O-:16])=[O:15].[CH2:27](N(CC)CC)C>C(Cl)Cl>[CH3:12][C:13]([CH3:26])([CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][N:23]([C:1](=[O:10])[CH:2]=[CH:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:22][CH2:21]1)[C:14]([O:16][CH3:27])=[O:15]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 660233-Phenylprop-2-enoyl chlorideHCID 20492829HCID 20492829, compound

Product 1

HCID 86738965HCID 86738965, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of cinnamoyl chloride (3.32 g) in methylene chloride (25 ml) is added dropwise to a solution of methyl, α,α-dimethyl-1-piperazinepentanoate (4.56 g) in methylene chloride (25 ml) containing triethylamine (2.0 g) and the mixture is stirred overnight at room temperature. The solution is washed with water, dried, and distilled to yield the product methyl α,α-dimethyl-4-(1-oxo-3-phenyl-2-propenyl)-1-piperazine pentanoate, mp 76° following crystallization from isopropyl ether.

Workup

  1. washThe solution is washed with water
  2. customdried
  3. distillationdistilled

Sources & evidence

ORD record
ord-9af3cb29b28e4da0ae75c05cca5e4546
Source dataset
uspto-grants-1983_08
Patent number
US04397855

Reaction notes

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