反应详情

To a solution of 7 g of ethyl 5-phenyl-4,5-dihydroisoxazol-3-ylcarboxylate in 70 ml of methanol, cooled with ice, is added 1.5 g of sodium borohydride in small portions with stirring. After 4 hours has passed, the solvent is distilled off under reduced pressure and the residue is extracted with ethyl acetate. The extract is washed with water, dried and the solvent is evaporated. The crystalline residue thus obtained is recrystallized from isopropyl ether, giving 3-hydroxymethyl-5-phenyl-4,5-dihydroisoxazole in the form of white crystals. Melting point: 73°-74° C.

1. distillationthe solvent is distilled off under reduced pressure
2. extractionthe residue is extracted with ethyl acetate
3. washThe extract is washed with water
4. customdried
5. customthe solvent is evaporated
6. customThe crystalline residue thus obtained
7. customis recrystallized from isopropyl ether