反应详情

19.4 g of 7-hydroxy-5-carboxymethyl-1,2,4-triazolo[1,5-a]pyrimidine and 12 g of hydroxyethylacrylate were dissolved in 150 ml of dimethylformamide (DMF) and thereto, a solution of 20.6 g of N,N-dicyclohexylcarbodiimide in 30 ml of DMF was added dropwise at a room temperature for 10 minutes. Thereafter, stirring was continued at a room temperature for 8 hours, and the precipitate produced was removed by filtration. The filtrate was condensed under a reduced pressure and low temperature. The thus obtained residue was chromatographed through silica gel put in a column in order to separate it into components and purify. The intended compound was obtained in a form of crystal. It was recrystallized from ethyl acetate. Thus, 6 g of white crystal having a melting point of 108° to 109° C. (intended compound) was obtained.

1. customthe precipitate produced
2. customwas removed by filtration
3. customcondensed under a reduced pressure and low temperature
4. customThe thus obtained residue was chromatographed through silica gel
5. customto separate it into components
6. custompurify
7. customThe intended compound was obtained in a form of crystal
8. customIt was recrystallized from ethyl acetate
9. customwas obtained