Methanol → Methyl 4-chloroacetoacetate

HRID 434558Notes

Reaction equation

HRID 434558 reaction equation
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[CH3:9][OH:10]>C(=O)(O)[O-].[Na+]>[CH3:9][O:10][C:4](=[O:6])[CH2:3][C:2]([CH2:7][Cl:8])=[O:5]

Participants

4

Reactant 2

HCID 887MethanolHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

Product 1

HCID 36240Methyl 4-chloroacetoacetate

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 200 parts of methanol containing 4.2 parts of anhydrous sodium bicarbonate. After stirring for 20 hours at room temperature, the solids are filtered off, the filtrate is evaporated and the residue distilled to give methyl-γ-chloroacetoacetate, b.p. 48°-50° C./0.8 mb.

Workup

  1. filtrationthe solids are filtered off
  2. customthe filtrate is evaporated
  3. distillationthe residue distilled

Sources & evidence

ORD record
ord-d07232691b404028acd22943814a09f4
Source dataset
uspto-grants-1983_08
Patent number
US04398033

Reaction notes

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