Sodium Hydroxide → HCID 13189003, compound

HRID 434573Notes

Reaction equation

HRID 434573 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:21])=[C:10]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)[C:11]=2[F:13])[C:6](=[O:22])[C:5]([C:23]([OH:25])=[O:24])=[CH:4]1)[CH3:2].[OH-].[Na+].[N+]([O-])([O-])=O.[Ag+:32]>O>[Ag+:32].[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:21])=[C:10]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)[C:11]=2[F:13])[C:6](=[O:22])[C:5]([C:23]([O-:25])=[O:24])=[CH:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24470Silver NitrateHCID 12770914HCID 12770914, compound

Product 1

HCID 13189003HCID 13189003, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a stirred solution of 1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxy-1-piperidinyl)-4-oxoquinoline-3-carboxylic acid (235 mg), sodium hydroxide (26.7 mg), and water (3 ml), a solution of silver nitrate (113 mg) and water (2 ml) was added. The precipitate was filtered off, washed with water, and dried to give 1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxy-1-piperidinyl)-4-oxoquinoline-3-carboxylic acid silver salt (284 mg), mp 181°-184° C. (decomp.).

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-9b6a4a7add5542a085a6e4e1f36433ce
Source dataset
uspto-grants-1983_08
Patent number
US04398029

Reaction notes

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