1-Bromo-3-methylbutan-2-one → 2-(3-Methyl-2-oxobutyl)-1h-isoindole-1,3(2h)-dione

HRID 43462Notes

Reaction equation

HRID 43462 reaction equation
Br[CH2:2][C:3](=[O:7])[CH:4]([CH3:6])[CH3:5].[C:8]1(=[O:18])[NH:12][C:11](=[O:13])[C:10]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:9]12.[K]>>[CH3:5][CH:4]([CH3:6])[C:3](=[O:7])[CH2:2][N:12]1[C:8](=[O:18])[C:9]2[C:10](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:11]1=[O:13]

Participants

3

Reactant 2

HCID 108990371-Bromo-3-methylbutan-2-oneHCID 24194345Phthalimide potassium salt

Product 1

HCID 2778112-(3-Methyl-2-oxobutyl)-1h-isoindole-1,3(2h)-dioneYield 74.1%

Procedure

The same operation as in Example (15b) was performed using 1-bromo-3-methylbutan-2-one obtained in Example (35a) (3.94 g, 23.9 mmol) and potassium phthalimide (4.4 g, 23.8 mmol), to obtain 4.08 g of the title compound as a white solid (74%).

Sources & evidence

ORD record
ord-d78db5d42f044ec790793357f13b9257
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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