反应详情

温度

115 °C

3,3-Dimethyl-4-hydroxybutan-2-one (11.2 g) was dissolved in 50 ml of dimethyl sulfoxide, and nitrogen gas was passed therethrough for 20 minutes. Then, 21.6 g of 2,3-dichloro-5-trifluoromethylpyridine and 15 g of anhydrous potassium carbonate were added thereto, and the system was gradually heated to 115° C. and stirred for 4 hours at that temperature. After completion of the reaction, the product was put into ice water, extracted with methylene chloride, washed with water and dried over Glauber's salt. The solvent was distilled off to give 26.7 g of oily 3,3-dimethyl-4-(3-chloro-5trifluoromethylpyridine-2-yloxy)butan-2-one.

1. customAfter completion of the reaction
2. extractionextracted with methylene chloride
3. washwashed with water
4. dry with materialdried over Glauber's salt
5. distillationThe solvent was distilled off