反应详情

温度

80 °C

N,N-Dimethylformamide dineopentyl acetal (1.5 ml) was added to a stirred suspension of 5-iodopyrimidin-2-one (777 mg) and 2-hydroxymethyl thiophene (0.62 ml) in dry N,N-dimethylformamide (8 ml) under nitrogen and the mixture was then heated at 80° C. After 13/4 h the reaction mixture was evaporated to a brown solid which was crystallised twice from ethyl acetate to give the title pyrimidinone (540 mg), m.p. 207°-209° C., λmax (EtOH) 232.5 nm (ε 21,820), 341.5 nm (ε 2,420).

1. customAfter 13/4 h the reaction mixture was evaporated to a brown solid which
2. customwas crystallised twice from ethyl acetate