Hydrazine hydrate (1:1) → HCID 20491753, compound

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Reaction Steps

A solution of 5-chloro-6-methyl-4-methylthio-1-(2-thienylmethyl)pyrimidin-2-one (987 mg) and hydrazine hydrate (98-100%) (2.5 ml) in ethanol (50 ml) was stirred and heated at reflux for one hour. The solution was evaporated to a gum which crystallised from ethanol to give pale purple crystals of the title pyrimidinone (649 mg) m.p. 184°-187° C.; λmax (EtOH) 232 nm (ε 14,720), 291.5 nm (ε 10,400).

Provenance & Evidence