Hydrazine hydrate (1:1) → HCID 20491753, compound

HRID 434662Notes

Reaction equation

HRID 434662 reaction equation
[Cl:1][C:2]1[C:3](SC)=[N:4][C:5](=[O:15])[N:6]([CH2:9][C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[C:7]=1[CH3:8].O.[NH2:19][NH2:20]>C(O)C>[Cl:1][C:2]1[C:3]([NH:19][NH2:20])=[N:4][C:5](=[O:15])[N:6]([CH2:9][C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20491779HCID 20491779, compound

Product 1

HCID 20491753HCID 20491753, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-chloro-6-methyl-4-methylthio-1-(2-thienylmethyl)pyrimidin-2-one (987 mg) and hydrazine hydrate (98-100%) (2.5 ml) in ethanol (50 ml) was stirred and heated at reflux for one hour. The solution was evaporated to a gum which crystallised from ethanol to give pale purple crystals of the title pyrimidinone (649 mg) m.p. 184°-187° C.; λmax (EtOH) 232 nm (ε 14,720), 291.5 nm (ε 10,400).

Workup

  1. temperatureheated
  2. temperatureat reflux for one hour
  3. customThe solution was evaporated to a gum which
  4. customcrystallised from ethanol

Sources & evidence

ORD record
ord-fb507e5925dc4a14b5d1a6dee1f4d0d7
Source dataset
uspto-grants-1983_08
Patent number
US04399140

Reaction notes

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