Hydrochloric Acid → HCID 70489399, compound

HRID 434690Notes

Reaction equation

HRID 434690 reaction equation
[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([OH:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH2:25][CH2:24][CH:23]([NH:26]C(=O)C)[CH2:22][CH2:21]1.[OH-].[Na+].[ClH:32]>>[ClH:32].[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([OH:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH2:21][CH2:22][CH:23]([NH2:26])[CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13044297HCID 13044297, compound

Product 1

HCID 70489399HCID 70489399, compound

Procedure

A mixture of 2 g of 9-fluoro-8-(4-acetylamino-1-piperidyl)-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid and 50 ml of a 10% aqueous sodium hydroxide solution was heated for 10 hours. After completion of reaction, the reaction mixture was cooled and adjusted to pH 4 with dilute hydrochloric acid (10%) to form precipitations, which then were recrystallized from ethanol-water to give 0.7 g of 9-fluoro-8-(4-amino-1-piperidyl)-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrochloride. m.p. not lower than 300° C., white rhombic crystals.

Workup

  1. temperaturewas heated for 10 hours
  2. customAfter completion of reaction
  3. temperaturethe reaction mixture was cooled
  4. customto form
  5. customprecipitations, which
  6. customthen were recrystallized from ethanol-water

Sources & evidence

ORD record
ord-e06f5d8aaba343e78e442786b0daad4f
Source dataset
uspto-grants-1983_08
Patent number
US04399134

Reaction notes

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