4-(Trifluoromethyl)aniline → Benzamide, 2-chloro-N-(((4-(trifluoromethyl)phenyl)amino)carbonyl)-

Participants

Reaction Steps

18.7 g of 2-chlorobenzoylisocyanate were added to 150 ml of a solution of 17.7 g of 4-trifluoromethylaniline in dry acetonitrile. After stirring at room temperature for a few hours, the crystalline precipitate was sucked off, washed with successively acetonitrile, ethanol and petroleum ether and dried in air. The desired product was obtained in a yield of 29.0 g; melting point 214° C.

Provenance & Evidence