Hydrochloric Acid → HCID 178479646, compound

HRID 434771Notes

Reaction equation

HRID 434771 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](=[O:22])[NH:10][CH:11]=[C:12]3[C:17]=2[NH:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[S:13]3)=[CH:4][CH:3]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17]3[NH:16][C:15]4[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=4[S:13][C:12]=3[CH:11]=[N:10][C:9]=2[OH:22])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13051480HCID 13051480, compound

Product 1

HCID 178479646HCID 178479646, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1 part 4-(4-chlorophenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one in 25 parts of concentrated hydrochloric acid is added 25 parts methanol. The solution is warmed to the mean boiling point of the alcohol. Another 50 parts of methanol is added and heating continued until nearly all the solid material is dissolved. The hot solution is filtered to remove undissolved solids and upon concentrating the solution volume of filtrate in a suction flask, yellow needles of 4-(4-chlorophenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3-ol hydrochloride result, melting above 300° C.

Workup

  1. temperatureThe solution is warmed to the mean
  2. temperatureheating
  3. dissolutionis dissolved
  4. filtrationThe hot solution is filtered
  5. customto remove undissolved solids
  6. concentrationupon concentrating the solution volume of filtrate in a suction flask

Sources & evidence

ORD record
ord-5de02b8250dc41f3b1a503dbaa28c604
Source dataset
uspto-grants-1983_08
Patent number
US04399279

Reaction notes

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