4,5-Diethyl-2-(dimethoxymethyl)-1H-imidazole → 4,5-Diethyl-1H-imidazole-2-carbaldehyde

HRID 43488Notes

Reaction equation

HRID 43488 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([CH:10](OC)[O:11]C)[NH:6][C:7]=1[CH2:8][CH3:9])[CH3:2]>S(=O)(=O)(O)O>[CH2:8]([C:7]1[N:6]=[C:5]([CH:10]=[O:11])[NH:4][C:3]=1[CH2:1][CH3:2])[CH3:9]

Participants

3

Reactant 1

HCID 675497474,5-Diethyl-2-(dimethoxymethyl)-1H-imidazole

Product 1

HCID 866485014,5-Diethyl-1H-imidazole-2-carbaldehydeYield 28.5%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

The same operation as in Example (33b) was performed using 4,5-diethyl-2-(dimethoxymethyl)-1H-imidazole obtained in Example (43a) (about 8.12 mmol) and 2 N sulfuric acid (40 mL), to obtain 352 mg of the title compound as a white solid (28%).

Sources & evidence

ORD record
ord-a6150407435c4edb957c99479a1a9cfe
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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