1-Hydroxybenzotriazole → HCID 86648502, compound

HRID 43490Notes

Reaction equation

HRID 43490 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][C@H:3]1[O:15][CH3:16].[CH2:17]([C:19]1[N:20]=[C:21]([C:26](O)=[O:27])[NH:22][C:23]=1[CH2:24][CH3:25])[CH3:18].CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>>[CH2:24]([C:23]1[N:22]=[C:21]([C:26]([NH:1][C@H:2]2[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9])[CH2:4][C@H:3]2[O:15][CH3:16])=[O:27])[NH:20][C:19]=1[CH2:17][CH3:18])[CH3:25]

Participants

5

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 57362389(3R,4S)-4-Amino-1-boc-3-methoxypiperidine2×HCID 684062254,5-diethyl-1H-imidazole-2-carboxylic acid

Product 1

HCID 86648502HCID 86648502, compound

Procedure

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1e) (120 mg, 0.52 mmol), 4,5-diethyl-1H-imidazole-2-carboxylic acid obtained in Example (43c) (36.7 mg, 0.22 mmol), WSC hydrochloride (145 mg, 0.76 mmol) and HOBT (35 mg, 0.26 mmol), to obtain 55.0 mg of the title compound as a white foamy substance (66%).

Workup

  1. customobtained by the method

Sources & evidence

ORD record
ord-eb70107ae7a74b7da098c25f8a0289f6
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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