Methanol → 2-(2-Aminothiazol-4-yl)-2-propargyloxyiminoacetic acid

HRID 434913노트

반응식

HRID 434913 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][C:16]#[CH:17])[C:8]([O:10]CC)=[O:9])[N:6]=1.CO.[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][C:16]#[CH:17])[C:8]([OH:10])=[O:9])[N:6]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 53907014Ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate

생성물 1

HCID 543726822-(2-Aminothiazol-4-yl)-2-propargyloxyiminoacetic acid수율 77.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate (syn isomer, 2.8 g.), methanol (23 ml.), tetrahydrofuran (20 ml.) and 1 N aqueous solution of sodium hydroxide (22.17 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetic acid (syn isomer, 1.924 g.).

출처 및 근거

ORD 기록
ord-1cc2ff3af7ae4126ac09744d88b761ed
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04399133

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