Potassium Carbonate → HCID 20490692, compound

Participants

Reaction Steps

8.4 g (0.05 mol) 2-Isopropylamino-6-hydroxy-6-methylpyrimidine, 6.9 g (0.05 mol) K2CO3, 6.9 g (0.05 mol) 1-methyl-2,2-dichlorocyclopropylmethylbromide and 100 ml absolute dimethylformamide are charged in a sulphonation flask and the mixture heated for 26 hours at a bath temperature of 110°. After cooling, the reaction mixture is filtered over diatomaceous earth and concentrated. The resulting orange-red oil is chromatographed on silica gel, using diethylether:n-hexane 1:1 as mobile phase. The title compounds is obtained as a yellow, clear oil, Rf value 0.25.

Provenance & Evidence