Potassium Carbonate → HCID 20490692, compound

HRID 435042Notes

Reaction equation

HRID 435042 reaction equation
[CH:1]([NH:4][C:5]1[NH:6][C:7]([OH:12])(C)[CH:8]=[CH:9][N:10]=1)([CH3:3])[CH3:2].[C:13]([O-])([O-])=O.[K+].[K+].[CH3:19][C:20]1([CH2:25]Br)[CH2:22][C:21]1([Cl:24])[Cl:23]>CN(C)C=O>[CH:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:13])[CH:8]=[C:7]([O:12][CH2:19][C:20]2([CH3:25])[CH2:22][C:21]2([Cl:24])[Cl:23])[N:6]=1)([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 14669175HCID 14669175, compoundHCID 178456846HCID 178456846, compound

Product 1

HCID 20490692HCID 20490692, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

8.4 g (0.05 mol) 2-Isopropylamino-6-hydroxy-6-methylpyrimidine, 6.9 g (0.05 mol) K2CO3, 6.9 g (0.05 mol) 1-methyl-2,2-dichlorocyclopropylmethylbromide and 100 ml absolute dimethylformamide are charged in a sulphonation flask and the mixture heated for 26 hours at a bath temperature of 110°. After cooling, the reaction mixture is filtered over diatomaceous earth and concentrated. The resulting orange-red oil is chromatographed on silica gel, using diethylether:n-hexane 1:1 as mobile phase. The title compounds is obtained as a yellow, clear oil, Rf value 0.25.

Workup

  1. temperaturethe mixture heated for 26 hours at a bath temperature of 110°
  2. temperatureAfter cooling
  3. filtrationthe reaction mixture is filtered over diatomaceous earth
  4. concentrationconcentrated
  5. customThe resulting orange-red oil is chromatographed on silica gel

Sources & evidence

ORD record
ord-46667634e33c477aa97a2d3b0408b2cf
Source dataset
uspto-grants-1983_08
Patent number
US04400201

Reaction notes

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