Acetone → HCID 12962350, compound

HRID 435052Notes

Reaction equation

HRID 435052 reaction equation
[C:1]1([CH:7]2[NH:11][CH2:10][CH2:9][S:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC(C)=O.C(N(CC)CC)C.[Cl:23][CH:24]([Cl:28])[C:25](Cl)=[O:26]>O>[C:1]1([CH:7]2[N:11]([C:25](=[O:26])[CH:24]([Cl:28])[Cl:23])[CH2:10][CH2:9][S:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 207062-phenyl-thiazolidine

Product 1

HCID 12962350HCID 12962350, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Five (5) grams of 2-phenyl thiazolidine was dissolved in 50 ml. of acetone, 3.1 g. of triethylamine was added and the mixture stirred in a room temperature water bath, while 4.4 g. of dichloroacetyl chloride was added dropwise. The mixture was allowed to stand for about 30 minutes and then poured into water, extracted with methylene chloride, separated, dried over magnesium sulfate, and the solvent stripped under vacuum. There was obtained a yield of 7.3 g. of an oil, the title compound, ND30 =1.5836.

Workup

  1. extractionextracted with methylene chloride
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 7.3 g

Sources & evidence

ORD record
ord-92ae31af26114950b77352e925719b03
Source dataset
uspto-grants-1983_08
Patent number
US04400200

Reaction notes

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