Hydrochloric Acid → HCID 20490686, compound

Participants

Reaction Steps

The compound of Example 1 (33.5 g) was added to methanol (500 ml) containing 5 ml concentrated hydrochloric acid, and the resulting mixture was refluxed for 21/2 hours. It was then cooled, the solvent was evaporated off and the residue was dissolved in diethyl ether. The solution was washed with neutral brine, dried over magnesium sulphate and evaporated to give 25.1 g of the desired product. This corresponds to a 100% yield. NMR showed the product to be a mixture of geometric isomers.

Provenance & Evidence