反应详情

The compound of Example 1 (33.5 g) was added to methanol (500 ml) containing 5 ml concentrated hydrochloric acid, and the resulting mixture was refluxed for 21/2 hours. It was then cooled, the solvent was evaporated off and the residue was dissolved in diethyl ether. The solution was washed with neutral brine, dried over magnesium sulphate and evaporated to give 25.1 g of the desired product. This corresponds to a 100% yield. NMR showed the product to be a mixture of geometric isomers.

1. temperaturethe resulting mixture was refluxed for 21/2 hours
2. temperatureIt was then cooled
3. customthe solvent was evaporated off
4. dissolutionthe residue was dissolved in diethyl ether
5. washThe solution was washed with neutral brine
6. dry with materialdried over magnesium sulphate
7. customevaporated