HCID 53950594, compound → HCID 54502876, compound

HRID 435069Notes

Reaction equation

HRID 435069 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:6][CH:5]([OH:7])[C:4]([CH2:10][O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([CH2:8][CH3:9])[O:3]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH3:19][C:2]1([CH3:1])[CH2:6][C:5](=[O:7])[C:4]([CH2:10][O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([CH2:8][CH3:9])[O:3]1

Participants

4

Reactant 2

HCID 53950594HCID 53950594, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 54502876HCID 54502876, compoundYield 73.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound of Example 26 (1.2 g), methylene chloride (10 ml) and pyridinium chlorochromate (1.08 g) were stirred together for 24 hours at ambient temperature. The resulting solution was filtered through a column of Fluorosil (Trade Mark) using methylene chloride as eluant. Evaporation of the solvent gave 0.87 g (73.7%) of the desired product.

Workup

  1. filtrationThe resulting solution was filtered through a column of Fluorosil (Trade Mark)
  2. customEvaporation of the solvent

Sources & evidence

ORD record
ord-c13f4224df3f4d239442aad304e0fc45
Source dataset
uspto-grants-1983_08
Patent number
US04400198

Reaction notes

Loading…