Morpholine → 1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydro-1H-purine-2,6-dione

HRID 435108Notes

Reaction equation

Br[C:2]1[NH:11][C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[O:18]1[CH2:19][CH2:20][N:15]([C:2]2[NH:11][C:10]3[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=3[N:3]=2)[CH2:16][CH2:17]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 11808Bromotheophylline

Product 1

HCID 7667721,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydro-1H-purine-2,6-dioneYield 80%

Procedure

0.3 moles of the 8-bromo-theophylline, prepared as in the previous paragraph, is refluxed in 1.5 moles of morpholine for two hours. The precipitate obtained is filtered, to give approximately 80% yield of 8-morpholino-theophylline.

Workup

customThe precipitate obtained
filtrationis filtered

Sources & evidence

ORD record: ord-122ed7faa1f54c038032af7d70cad165
Source dataset: uspto-grants-1983_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04400381

Reaction notes

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