反应详情

To 1 liter 50% aqueous alcohol are added 3 moles piperazine, 1 mole 3-phenylthio-1-chloropropane, 1 mole 10N sodium hydroxide. The mixture is refluxed for 24 hours, with stirring. The methanol is then evaporated off, and the resulting material is extracted with methylene chloride. The organic phase is thoroughly washed with water, and is then concentrated and distilled, to give 1-(3-phenylthiopropyl)piperazine, bp0.5 mm =140°-142° C.

1. temperatureThe mixture is refluxed for 24 hours
2. customThe methanol is then evaporated off
3. extractionthe resulting material is extracted with methylene chloride
4. washThe organic phase is thoroughly washed with water
5. concentrationis then concentrated
6. distillationdistilled