Hydrochloric Acid → HCID 53761295, compound

HRID 435183Notes

Reaction equation

HRID 435183 reaction equation
[CH3:1][C:2]1([CH3:19])[CH:7]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[O:10])[O:6][C:4](=[O:5])[CH2:3]1.[ClH:20].[CH2:21](O)[CH3:22]>>[CH2:21]([O:6][C:4](=[O:5])[CH2:3][C:2]([CH3:19])([CH3:1])[CH:7]([Cl:20])[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)=[O:10])[CH3:22]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 20474521HCID 20474521, compound

Product 1

HCID 53761295HCID 53761295, compound

Procedure

78.6 g of 3,3-dimethyl-4-(4'-methoxy-phenacyl)-γ-butyrolactone were dissolved in 500 ml of ethanol, and dry hydrogen chloride was passed in until the temperature had reached 50° C. A slow stream of hydrogen chloride was then passed through the solution at 50° C., initially while cooling, for 3 hours, and then continued to be passed in until the mixture reached room temperature again. Distilling off the ethanol in vacuo gave 98 g of 6-(4'-methoxy-phenyl)-6-oxo-4-chloro-3,3-dimethyl-hexanoic acid ethyl ester.

Workup

  1. customhad reached 50° C
  2. customwas then passed through the solution at 50° C.
  3. temperatureinitially while cooling, for 3 hours
  4. customreached room temperature
  5. distillationDistilling off the ethanol in vacuo

Sources & evidence

ORD record
ord-3b29db0fbcb84b61872438782b47cc6a
Source dataset
uspto-grants-1983_08
Patent number
US04400523

Reaction notes

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