反应详情

4,6-Diacetyl resorcinol (485 g, 2.5 m) sodium hydroxide (220 g, 5 m), 1-iodobutane (285 ml, 2.5 m) and water (2 l) were heated on a steam bath for 16 hours, cooled to 20° and the yellow-white precipitate filtered and washed with water. The solid was washed with dilute hydrochloric acid, extracted into chloroform (2×1.5 l) and the chloroform solution washed with water (2 l) and brine (1 l), then dried (anhyd. Na2SO4). Filtration and removal of solvent gave an oil (420 g) which crystallised on standing.

1. temperaturecooled to 20°
2. filtrationthe yellow-white precipitate filtered
3. washwashed with water
4. washThe solid was washed with dilute hydrochloric acid
5. extractionextracted into chloroform (2×1.5 l)
6. washthe chloroform solution washed with water (2 l) and brine (1 l)
7. dry with materialdried (anhyd. Na2SO4)
8. filtrationFiltration and removal of solvent