反应详情

To a solution of 1-phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanone (675 g, 0.0025 mol) in methanol (40 mL) was added sodium borohydride (300 mg, 0.0079 mol) in portions and the mixture allowed to stir at room temperature for one hour. The reaction mixture was concentrated, diluted with water, and extracted with ether (3×25 mL). The combined extracts were washed with brine, dried over magnesium sulfate, concentrated, and chromatographed. Recrystallization from hexane/ethyl acetate afforded 1-phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanol (300 mg, 45%). mp. 146°-147° C.

1. concentrationThe reaction mixture was concentrated
2. additiondiluted with water
3. extractionextracted with ether (3×25 mL)
4. washThe combined extracts were washed with brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. customchromatographed
8. customRecrystallization from hexane/ethyl acetate