反应详情

The same operation as in Example (77d) was performed using ethyl cis(±)-2-(3-amino-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-benzothiazole-7-carboxylate obtained in Example (81e) (38 mg, 0.080 mmol), 1-propanal (7 μL, 0.097 mmol) and sodium (triacetoxy)borohydride (80 mg, 0.38 mmol), to obtain 31.9 mg of the title compound as a white solid (77%).