3,4-dihydro-2H-pyran → 2-(3-Bromo-2-methoxyphenoxy)oxane

HRID 435509Notes

Reaction equation

HRID 435509 reaction equation
[Br:1][C:2]1[C:3]([O:9][CH3:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[O:11]1[CH:16]=[CH:15][CH2:14][CH2:13][CH2:12]1>>[CH3:10][O:9][C:3]1[C:4]([O:8][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][O:11]2)=[CH:5][CH:6]=[CH:7][C:2]=1[Br:1]

Participants

3

Reactant 2

HCID 80803,4-dihydro-2H-pyranHCID 218775343-Bromo-2-methoxyphenol

Product 1

HCID 540942552-(3-Bromo-2-methoxyphenoxy)oxane

Procedure

Treatment of 3-bromo-2-methoxyphenol with dihydropyran and an acid catalyst as described herein affords 2-methoxy-3-tetrahydropyranyloxy-1-bromobenzene.

Sources & evidence

ORD record
ord-77ac402e0bfd4e74a183c4bcdc7404b5
Source dataset
uspto-grants-1983_08
Patent number
US04401824

Reaction notes

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