Ammonium formate → HCID 67548762, compound

HRID 43560Notes

Reaction equation

HRID 43560 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:14]=2)=[CH:6][CH:5]=1)([O-])=O.C([O-])=O.[NH4+]>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[S:11][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:14]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 53403660Ethyl 2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate

Product 1

HCID 67548762HCID 67548762, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The same operation as in Example (90d) was performed using ethyl 2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate obtained in Example (91a) (0.18 g, 0.65 mmol), 10% Pd/C (wet, 0.1 g), ammonium formate (0.2 g, 3.24 mmol) and methanol (5 mL), to obtain 0.12 g of the crude title compound as a yellow solid (75%).

Sources & evidence

ORD record
ord-f159961492304b7fa8cfe93bf2bb857f
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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