1,2-Ethanediamine, N1,N1,N2-trimethyl- → HCID 21455958, compound

HRID 435601Notes

Reaction equation

HRID 435601 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[N:11]3[N:12]=[C:13](Cl)[CH:14]=[CH:15][C:10]3=[N:9][N:8]=2)=[CH:5][N:4]=[C:3]1[N+:17]([O-:19])=[O:18].[CH3:20][NH:21][CH2:22][CH2:23][N:24]([CH3:26])[CH3:25]>CN(C)C=O>[CH3:1][N:2]1[C:6]([C:7]2[N:11]3[N:12]=[C:13]([N:21]([CH3:20])[CH2:22][CH2:23][N:24]([CH3:26])[CH3:25])[CH:14]=[CH:15][C:10]3=[N:9][N:8]=2)=[CH:5][N:4]=[C:3]1[N+:17]([O-:19])=[O:18]

Participants

4

Reactant 2

HCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 21456014HCID 21456014, compound

Product 1

HCID 21455958HCID 21455958, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.65 g. 3-(1-methyl-2-nitro-5-imidazolyl)-6-chloro-s-triazolo[4,3-b]pyridazine were reacted in 13 ml. dimethyl formamide with 0.5 g. trimethylethylenediamine at 60° C. for 15 minutes. After working up the reaction mixture in a manner analogous to that described in Example 47, there was obtained 0.6 g. (75% of theory) of the desired 3-(1-methyl-2-nitro-5-imidazolyl)-6[N-methyl-N-(β-dimethyl-aminoethyl)-amino]-s-triazolo[4,3-b]pyridazine in the form of yellow crystals which have a melting point of 196° - 198° C.

Workup

  1. customthere was obtained 0.6 g

Sources & evidence

ORD record
ord-8f42fffeff6f45c58b89f340a2006240
Source dataset
uspto-grants-1977_02
Patent number
US04006141

Reaction notes

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