反应详情

To a cooled, stirred mixture of 3 g. of 1,2,4-triazole-3-carboxamide and 4 g. of benzoyl chloride in 125 ml. of anhydrous diethyl ether is added rapidly 2.75 g. of triethylamine. The cooling bath is removed and the mixture is stirred at room temperature for 18 hours. The heterogeneous mixture is filtered and washed successively with diethyl ether, cold water and then diethyl ether and dried in vacuo for 4 hours yielding 4 g. of colorless solid. This solid is extracted with hot, dry acetonitrile and cooled yielding a solid product which is collected, washed with acetonitrile and dried in vacuo, yielding 1 g. of product, m.p. 174°-178° C. (dec.).

1. additionmixture of 3 g
2. customThe cooling bath is removed
3. stirringthe mixture is stirred at room temperature for 18 hours
4. filtrationThe heterogeneous mixture is filtered
5. washwashed successively with diethyl ether, cold water
6. dry with materialdiethyl ether and dried in vacuo for 4 hours
7. customyielding 4 g
8. extractionThis solid is extracted with hot, dry acetonitrile
9. temperaturecooled
10. customyielding a solid product which
11. customis collected
12. washwashed with acetonitrile
13. customdried in vacuo
14. customyielding 1 g