反应详情

A solution of pyridinium hydrobromide perbromide (2.33 g, 0.0073 mol) in acetic acid (20 mL) containing 31% hydrobromic acid in acetic acid (1.85 mL) was stirred at room temperature for four hours. The mixture was cooled to 17° C. and a solution of 3-methoxy-4-acetylpyridine (1.02 g, 0.0062 mol) in acetic acid (5 mL) was added. The cooling bath was removed and after about thirty minutes a yellow solid was deposited. Ether (25 mL) was added and the crude α-bromo-3-methoxy-4-acetylpyridine hydrobromide (1.60 g) was collected by filtration washed with ether and air dried.

1. temperatureThe mixture was cooled to 17° C.
2. customThe cooling bath was removed and after about thirty minutes a yellow solid
3. additionEther (25 mL) was added
4. filtrationthe crude α-bromo-3-methoxy-4-acetylpyridine hydrobromide (1.60 g) was collected by filtration
5. washwashed with ether and air
6. customdried