反应详情

Valeryl chloride (12.06 g., 0.10 mole) is added dropwise to a cooled stirred solution of 4-nitroaniline (13.81 g., 0.10 mole) in pyridine (100 ml.). The resulting mixture is stirred at ambient temperature for one hour then heated (80°-100° C.) for twenty-four hours. The cooled solution is poured into cold 1 N hydrochloric acid (500 ml.) with stirring. The precipitated solid is collected, washed with water and dried, 21.4 g., m.p. 107°-116° C. Recrystallization from butyl chloride provides material of m.p. 115°-118° C.

1. temperaturethen heated (80°-100° C.) for twenty-four hours
2. stirringwith stirring
3. customThe precipitated solid is collected
4. washwashed with water
5. customdried
6. customRecrystallization from butyl chloride
7. customprovides material of m.p. 115°-118° C.