反应详情

30 g. (0.15 mole) of 1,8-naphthalimide and 12.5 ml. of 37% aqueous formaldehyde (0.17 mole) are combined in 100 ml. of dimethylformamide and heated on a hot plate (90°-110°) until all the materials dissolve. The solution is then allowed to stand overnight at 25°. The resulting precipitate is filtered off, washed with water and recrystallized from dioxane. This material is dried overnight at 25° (0.1 mm.) to yield 26.4 g. of the titled compound which has an indistinct melting point.

1. dissolutiondissolve
2. filtrationThe resulting precipitate is filtered off
3. washwashed with water
4. customrecrystallized from dioxane
5. customThis material is dried overnight at 25° (0.1 mm.)
6. customto yield 26.4 g