HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 59615468, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl trans(+/-)-2-[(2-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-5-yl)carbamoyl]cyclopropanecarboxylate | HCID 68414544 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 59615468 | HCID 59615468 | 76% |
Reaction Steps
The same operation as in Example (91d) was performed using ethyl trans(±)-2-[(2-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-5-yl)carbamoyl]cyclopropanecarboxylate obtained in Example (98b) (100 mg, 0.23 mmol), 2 N lithium hydroxide (3 mL, 6 mmol) and methanol (3 mL), to obtain 71 mg of the title compound as a colorless solid (76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-42ce4fd76ee0402e97a719680e754654 |
| Source note | uspto-grants-2013_09 |