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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43582Generated: October 28, 2026

Lithium Hydroxide → HCID 59615468, compound

https://huagongshe.com/reaction/43582

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
ReactantEthyl trans(+/-)-2-[(2-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-5-yl)carbamoyl]cyclopropanecarboxylateHCID 68414544—
SolventMethanolHCID 887—
ProductHCID 59615468HCID 5961546876%

Reaction Steps

The same operation as in Example (91d) was performed using ethyl trans(±)-2-[(2-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-5-yl)carbamoyl]cyclopropanecarboxylate obtained in Example (98b) (100 mg, 0.23 mmol), 2 N lithium hydroxide (3 mL, 6 mmol) and methanol (3 mL), to obtain 71 mg of the title compound as a colorless solid (76%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-42ce4fd76ee0402e97a719680e754654
Source noteuspto-grants-2013_09